Fig. 7: Schematic diagram of the mechanisms by which BBR ameliorates the blockade of autophagic flux induced by cholesterol overloading. | Cell Death & Disease

Fig. 7: Schematic diagram of the mechanisms by which BBR ameliorates the blockade of autophagic flux induced by cholesterol overloading.

From: Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis

Fig. 7

BBR could (1) down-regulate SCP2 and inhibit cholesterol trafficking toward plasma membrane; (2) activate CYP7A1 expression and induce bile acid synthesis; and (3) mitigate COX2-mediated prostaglandin synthesis, which together led to the inhibition of AKT/mTOR phosphorylation and improved autophagic flux

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