Fig. 2: CD59 deficiency increases the radiosensitivity of ESCC. | Cell Death & Disease

Fig. 2: CD59 deficiency increases the radiosensitivity of ESCC.

From: CD59 is a potential biomarker of esophageal squamous cell carcinoma radioresistance by affecting DNA repair

Fig. 2

a The confirmation of CD59 deficiency. b CD59 deficiency suppressed the cell proliferation of Eca109 cells either with or without ionizing radiation. UT untreated. c–f CD59 deficiency impaired the colony formation ability of Eca109 (c, d) and KYSE510 (e, f) cells after ionizing radiation. The survival fraction was analyzed by a linear quadratic (LQ) model in (d) and (f). g CD59 deficiency significantly suppressed tumor growth compared with CD59 sufficiency in xenograft mice bearing Eca109 cells after irradiation treatment (n = 5). h, i The images of mice and corresponding tumors (h) and tumor weights (i) at the endpoint of the experiment (n = 5). Data represent the mean ± SD, n = 3 unless otherwise indicated, *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001

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