Fig. 4: CD59 deficiency reduces the phosphorylation of Src (Y416). | Cell Death & Disease

Fig. 4: CD59 deficiency reduces the phosphorylation of Src (Y416).

From: CD59 is a potential biomarker of esophageal squamous cell carcinoma radioresistance by affecting DNA repair

Fig. 4

a-d CD59 deficiency resulted in the failure of Src activation after irradiation. Irradiation induced the activation of Src at 12 h in CD59-sufficient Eca109 cells, which was determined by the increased phosphorylation of the active site Y416 (a-d) but not that of inhibitory site Y529 (a). However, Src remained inactive in CD59-deficient cells either with or without irradiation (a-d). The western blot assay in (a) and the immunofluorescence assay in (b-d)

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