Fig. 2: Grhl3–/– embryonic skin shows compromised barrier integrity and increased expression of pro-proliferative cytokines.
From: Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis
Infiltrating γδT cells (a, b; immunohistochemistry; arrows. Scale bars correspond to 50 μm) and elevated numbers of mast cells (c, d) are seen in the skin of Grhl3–/– but not WT at E18.5, indicative of compromised epidermal integrity. Examination of the T-cell marker CD3 (e, f) shows increased expression in the dermis and epidermis of E18.5 Grhl3–/– embryos associated with epidermal activation of the inflammatory/proliferative marker STAT3 (g, h). Scale bars correspond to 70 μm
