Fig. 4: aP2-Prdm4 Tg male mice increase energy expenditure in HFD feeding. | Cell Death & Disease

Fig. 4: aP2-Prdm4 Tg male mice increase energy expenditure in HFD feeding.

From: PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice

Fig. 4

a, b Energy expenditure was evaluated by oxygen consumption and carbon dioxide production. a O2 consumption and b CO2 production rates of littermate control NonTg and Prdm4 Tg male mice were measured by indirect calorimetry using CLAMS after 6 weeks on HFD (n = 7 per group). Bar graph (right panel) represents the average of O2 consumption or CO2 production in each group. c Rectal temperature was measured in NonTg and aP2-Prdm4 Tg male mice during cold exposure at 4 °C. d Corrected food intake in NonTg and aP2-Prdm4 Tg male mice. e Ambulatory activities, and f Respiratory exchange ratio (RER) of NonTg and aP2-Prdm4 Tg HFD-fed mice (n = 7 per group). Data represent mean ± s.e.m. and statistically significant differences between control NonTg and aP2-Prdm4 Tg mice were determined by Student’s t-test. Statistically significant differences were determined by two-way ANOVA for the rectal temperature. *P < 0.05; **P < 0.005

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