Fig. 6: PARP12 regulates HCC cell migration and invasion. | Cell Death & Disease

Fig. 6: PARP12 regulates HCC cell migration and invasion.

From: PARP12 (ARTD12) suppresses hepatocellular carcinoma metastasis through interacting with FHL2 and regulating its stability

Fig. 6

a PARP12 deficiency promotes QGY-7703 and Huh7 cell migration. Representative images of the effect of PARP12 deficiency on migrated cells are shown and originally magnified 400×. The histograms show the mean numbers of migrated cells from three independent tests (mean ± s.d.). **P < 0.01, ****P < 0.0001. Scale bars = 50 µm. b PARP12 deficiency promotes QGY-7703 and Huh7 cell invasion. Representative images of the effect of PARP12 deficiency on cell invasion are shown and originally magnified 400×. The histograms show the mean numbers of invasive cells from three independent tests (mean ± s.d.). ****P < 0.0001. Scale bars = 50 μm. c Wild-type and enzyme-inactive mutant PARP12 reconstitutions decreased the migration and invasion of PARP12-deficient QGY-7703 cells. Representative images of migrated and invaded cells are shown and originally magnified 400×. The histograms show the mean numbers of migrated and invaded cells from three independent tests (mean ± s.d.). **P < 0.01, ***P < 0.001, ****P < 0.0001. Scale bars = 50 µm. d FHL2 overexpression decreased the migration and invasion of PARP12-deficient QGY-7703 cells. Representative images of migrated and invaded cells are shown and originally magnified 400×. The histograms show the mean numbers of migrated and invaded cells from three independent tests (mean ± s.d.). ****P < 0.0001. Scale bars = 50 µm

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