Fig. 7: PARP12 deficiency promotes tumor metastasis in vivo. | Cell Death & Disease

Fig. 7: PARP12 deficiency promotes tumor metastasis in vivo.

From: PARP12 (ARTD12) suppresses hepatocellular carcinoma metastasis through interacting with FHL2 and regulating its stability

Fig. 7

a–c PARP12 deficiency promotes tumor metastasis. PARP12 wild-type and -deficient QGY-7703 cells were injected into the nude mice through the tail vein. Representative images of metastatic tumors in the lung (a) and the H&E staining results, scale bars = 2.0 mm, (b) are shown. The scatter gram (c) shows the numbers of tumor nodules of each mouse (n = 7). **P < 0.01, ***P < 0.001. d–f Wild-type and enzyme-inactive mutant PARP12 reconstitutions decreased the tumor metastasis of PARP12-deficient QGY-7703 cells. PARP12 wild-type, -deficient, and -reconstituted QGY-7703 cells were injected into the nude mice through the tail vein. Representative images of metastatic tumors in the lung (d) and the H&E staining results, scale bars = 2.0 mm, (e) are shown. The scatter gram (f) shows the number of tumor nodules of each mouse (n = 7). ***P < 0.001, ****P < 0.0001

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