Fig. 7: Schematic representation of the effects of MRE11 inhibition on MYCN-dependent tumors.
From: MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors
While promoting an increased proliferation rate, MYCN overexpression also causes high levels of RS, which in turn would be responsible for the accumulation of DNA damage and cell death, if improperly controlled. However, MYCN regulates the expression of MRE11 to keep the deleterious effects of RS in check, thus allowing survival and proliferation of MYCN-driven tumor cells. Under these conditions, MRE11 inhibition leads to accumulation of RS-dependent DNA damage, DDR activation, and p53-dependent cell death
