Fig. 7: BEZ235 and TST displayed synergistic effect on DNA synthesis inhibition. | Cell Death & Disease

Fig. 7: BEZ235 and TST displayed synergistic effect on DNA synthesis inhibition.

From: HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation

Fig. 7

a T47D and b BT474 cells were seeded in 96-well plate and treated with TST plus BEZ235 for 36 h. Then, EdU was added to each well for 2 h. Images were taken by using fluorescence microscopy. c, d EdU-positive cell was calculated with (EdU add-in cells/Hoechst-stained cells) × 100%. ***P < 0.001. Data shown are mean ± SEM of at least three independent experiments, scale bar: 30 μm

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