Table 1 Histology details of KRAS-c.35G mutant adenomas

From: Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity

Sample ID

No. of FFPE blocks

% Fractional abundance in FFPE samples

Histology

Polyp dimensions (mm)

H146

1

9.4001

Transverse (benign HP)

8 × 5 × 4

H151

1

3.1402

Splenic flexure (LG TA)

5 × 4

H154

4

0.0000–10.8343

Descending-sigmoid (LG TA/TVA)

17 × 15 × 14

H185

1

1.2587

Sigmoid (LG TVA)

10 × 8 × 17

H189

1

18.612

Rectal (LG TA)

12

H263

11

0.0000–6.2256

Rectal (LG+HG TVA, focal AC)

17 × 30 × 10−30 × 25 × 22

H265

13

19.5678–37.4255

Distal sigmoid (LG+HG VA)

55 × 35 × 20

H266

9

12.9668–26.7434

Sigmoid (LG VA)

N/A

H321

1

0.9613

Colonic (LG+HG TVA)

15 × 7

H325

1

1.0923

Colonic (LG TVA)

20 × 14 × 8

H329

2

4.5123–9.0246

Rectal (LG VA)

11 × 9 × 9−14 × 9 × 7

H333

2

6.2192–8.3315

Recto-sigmoid (LG TA)

19 × 16 × 10

H334

2

0.0000–1.5870

Recto-sigmoid (LG TA+TVA)

7 × 9 × 4–12 × 10 × 4

H335

2

2.8364–8.9973

Sigmoid-cecal (LG TVA)

10–12

H336

2

5.3522–11.8328

Sigmoid (LG TVA)

14

H339

2

0.0005–1.2086

Recto-sigmoid (LG TA)

6 × 5 × 5−12 × 8 × 8

H343

2

0.7317–1.3000

Sigmoid (LG TVA)

15 × 10 × 15

H344

2

2.1852–2.8104

Colonic (LG TVA)

20 × 20 × 10

H345

2

0.0016–1.5049

Descending-sigmoid (LG TA)

7 × 5 × 4–11 × 9 × 7

H346

2

0.0003–2.5250

Ascending-rectal (LG TA)

12−15

H347

2

0.7243–1.8001

Recto-sigmoid (LG TVA)

21 × 15 × 10

H693

2

0.3259–1.6247

Cecal (LG TA)

N/A

H696

2

7.0348–7.4390

Ascending (LG TVA)

N/A

H697

1

5.4522

Cecal (LG TA)

10 × 4 × 2

H774

2

9.3524–18.4350

Cecal (AC Duke’s B)

N/A

H783

2

13.9502–14.6877

Distal descending (HG TVA with focal AC)

N/A

H784

2

18.9137–23.7891

Colonic (polyp–HG VA, AC–invasive, pT1)

N/A

  1. For cases where more than one FFPE blocks were tested, lowest and highest mutation frequencies are reported
  2. HP hyperplastic polyp, LG low-grade, HG high-grade, TA tubular adenoma, VA villous adenoma, TVA tubulovillous adenoma, MD mild