Fig. 2: MHYs inhibit tumor progression in a mouse xenograft model. | Cell Death & Disease

Fig. 2: MHYs inhibit tumor progression in a mouse xenograft model.

From: Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer

Fig. 2

a At 7 days after HT29 cell inoculation, mice harboring human colon tumors were treated with vehicle (control) or MHYs (3 mg/kg) for additional 8 days. Tumor growth was measured in control-treated and MHY-treated groups (n = 8 control, n = 5 MHY791, n = 6 MHY1036). b Representative tumor image of each treatment group. c Tumor weight was measured (n = 6). d Cleaved PARP and phosphorylation of ERK1/2 levels were evaluated in MHY-treated xenografts. Relative density measurements correspond to the intensities of the immunoblotting bands normalized to an internal control (n = 3). e TUNEL assays were performed in MHY-treated xenografts. Scale bar, 50 μm. Data are shown as mean ± SEM. Statistical significance was determined by two-way ANOVA followed by Bonferroni’s post-hoc test. Statistical significance is indicated as *p < 0.05, **p < 0.01, ***p < 0.001 ****p < 0.0001

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