Fig. 2: GICs treated with AZD8055 and rapamycin showing that autophagy suppressed GICs proliferation and self-renewal. | Cell Death & Disease

Fig. 2: GICs treated with AZD8055 and rapamycin showing that autophagy suppressed GICs proliferation and self-renewal.

From: Autophagy suppresses self-renewal ability and tumorigenicity of glioma-initiating cells and promotes Notch1 degradation

Fig. 2

a The representative images of GICs neurospheres showed that neurosphere formation ability of GICs was significantly inhibited by AZD8055 and rapamycin treatment. n = 5, Scale bar = 200 µm. b The quantification of numbers and diameter of the GICs neurospheres showing that neurosphere formation ability of GICs were obviously inhibited after AZD8055 and rapamycin treatment. c The ability of GICs proliferation were showed by cell viability assay. d The ability of GICs self-renewal was detected by in vitro limiting dilution assay. Data are shown as means ± s.d, n = 5, #P = NS, *P < 0.05, **P < 0.01, likelihood ratio test. Data in b, c are shown as means ± s.d., n = 5, *P  < 0.05, **P  < 0.01, Student’s t-test

Back to article page