Fig. 3: Pyroptosis induced by As2O3 in hepatocytes is NLRP3 inflammasome-dependent. | Cell Death & Disease

Fig. 3: Pyroptosis induced by As2O3 in hepatocytes is NLRP3 inflammasome-dependent.

From: Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway

Fig. 3

a Effects of As2O3 on cell viability in HepG2 cells. b The release of LDH after treatment with As2O3. (c)The efficiency of MCC950, and its effect on caspase-1 activation and IL-1β production in As2O3-treated HepG2 cells. d Effects of As2O3 and MCC950 on LDH release rate in HepG2 cells. e Effects of MCC950 on As2O3-induced double-positivity for PI and activated caspase-1 staining. f Effects of MCC950 on the As2O3-induced accumulation of lipids. a *P < 0.05 compared with 24 h control, #P < 0.05 compared with 48 h control. b–i Values are mean ± SD, and n = 3. *P < 0.05 compared with control group, #P < 0.05 compared with the As2O3 group; Scale bar = 50 μm

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