Fig. 4: CTSB mediated the As2O3-induced activation of NLRP3 inflammasomes and pyroptotic cell death. | Cell Death & Disease

Fig. 4: CTSB mediated the As2O3-induced activation of NLRP3 inflammasomes and pyroptotic cell death.

From: Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway

Fig. 4

a The efficiency of CA-074 Me, and its effect on caspase-1 activation and IL-1β production in As2O3-treated HepG2 cells, and densitometric analyses of NLRP3, caspase-1 p20, and IL-1β. b Effects of As2O3 and CA-074 on LDH release rate in HepG2 cells. c Effects of CA-074 Me on As2O3-induced double-positive PI and activated caspase-1 staining. d Detection of cytosolic and lysosomal CTSB levels after As2O3 and CA-074 Me treatments. e Effects of CA-074 Me on the As2O3-induced accumulation of lipid. Values are mean ± SD, and n = 3. *P < 0.05 compared with the control group, #P < 0.05 compared with the As2O3 group; Scale bar = 50 μm

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