Fig. 2: Depletion of PYK2 affects the protein level of TAZ and the Ser127 phosphorylation of YAP in TNBC cell lines. | Cell Death & Disease

Fig. 2: Depletion of PYK2 affects the protein level of TAZ and the Ser127 phosphorylation of YAP in TNBC cell lines.

From: PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein

Fig. 2

a WB analysis of TAZ protein level and YAP Ser127 phosphorylation in control and PYK2- or FAK-depleted TNBC cell lines. Quantification is shown as fold of control. b Subcellular localization of YAP in control and PYK2- or FAK-depleted TNBC cell lines (HCC1937, BT20), were examined by IF analysis. Scale bar, 10 μm. c The percentage of cells with nuclear (N) or cytosolic (C) YAP-staining was quantified based on the criteria shown below the graph (mean; n = 3)

Back to article page