Fig. 7
From: Linc02527 promoted autophagy in Intrahepatic cholestasis of pregnancy
Autophagy was involved in growth of fetal mouse. a–c The serum TBA, ALT and AST were detected in in ICP in the rat model. d The expression of LC3-II was detected in the placenta of ICP rat or NP group(normal control). e–i Forty C57 pregnant mice were randomly divided into four groups: group NC(E1), group RAPA(E2), group CQ(E3) and group CQ + RAPA(E4). From day 12 of gestation of gestation, mice in group NC were injected intraperitoneally with normal saline for 6 days consecutively. Group RAPA were injected intraperitoneally with rapamycin (5 mg/kg). Group CQ were injected intraperitoneally with chloroquine (50 mg/kg). Group RAPA + CQ were injected intraperitoneally with rapamycin (5 mg/kg) and chloroquine (50 mg/kg). On day 21 of gestation, the pregnant mice were sacrificed. Then, the fetal mice was calculated for body weight, fetus number, bodylenth and placenta weight. Error bars represented standard error. Asterisks(*) and **indicated p < 0.05 and 0.001, respectively
