Fig. 4: Myeloid A1 deletion worsens neuronal loss and retinal thinning after IR injury. | Cell Death & Disease

Fig. 4: Myeloid A1 deletion worsens neuronal loss and retinal thinning after IR injury.

From: Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fig. 4

a Retinas of mice with myeloid but not endothelial-specific A1 deletion showed worsened neuron loss compared to floxed control at 7 days after IR injury. Scale bar = 100 μm. b Quantification of NeuN-positive cells, n = 9 for A1f/f IR and 5 for M-A1−/− and E-A1−/− IR, *p < 0.05 vs. A1f/f. c H&E staining at 7 days showed worsened inner retina thinning in M-A1−/− mice compared to control (A1f/f). Scale bar = 50 μm. d Quantification of inner retina thickness, n = 7 for A1f/f IR and 6 for M-A1−/− IR, *p < 0.05. e Optical coherence tomography (OCT) corroborated the H&E results with yellow arrow pointing at retinal detachment

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