Fig. 1: POFUT1 is overexpressed in colorectal cancer tissues.
From: POFUT1 promotes colorectal cancer development through the activation of Notch1 signaling
a The top 20 overexpressed genes in colorectal cancer tissues from Cosmic database (https://cancer.sanger.ac.uk/cosmic/). A “Mutation Matrix” plot between genes and samples for colorectal tissue which contains top 20 ranked genes (rows) and TCGA samples (columns) with each box representing a Gene-Sample combination. POFUT1 genes ranked 5in colorectal cancer tissues (Only some TCGA samples are listed here, more details can be found in website). b The mRNA expression of POFUT1 in colorectal cancer tissues from TCGA colorectal cancer tissues, this figure generated by GEPIA (http://gepia.cancer-pku.cn/index.html), which is a newly developed interactive web server for analyzing the RNA sequencing expression data of 9736 tumors and 8587 normal samples from the TCGA and the GTEx projects, using a standard processing pipeline. (The number of cancer tissue (C) is 275; the number of normal tissue (N) is 41). c The mRNA expression of POFUT1 in our 35 pairs of human CRC tissues (C) and adjacent non-tumor tissues (N). *p < 0.05. d The protein expression of POFUT1 in six representative pairs of primary CRC (N) and adjacent non-tumor tissues (N). e Quantification of d. *p < 0.05. f The mRNA expression of POFUT1 in four colorectal cells lines (SW480, SW620, HCT116, and HT29); a normal human colon epithelial cell lines (NCM460) and human normal colon tissues
