Fig. 7: Lnc-INSR induced the Treg distribution while suppression the CTL function. | Cell Death & Disease

Fig. 7: Lnc-INSR induced the Treg distribution while suppression the CTL function.

From: Bone marrow infiltrated Lnc-INSR induced suppressive immune microenvironment in pediatric acute lymphoblastic leukemia

Fig. 7

a Different percentage of Treg in T cells treated with lnc-INSR in polarization stimulation assay. Quantitative calculation was listed in the right. b The CTL-suppression assay of Lnc-INSR was performed by mix culture of various types of CD4+ cell, CD8+, and OVA-induced DC cells. The ratio of cd4 and Cd8 cell ratio was evaluated by flow cytometry and presented in the right panel. c The cytolytic activity of the generated CTLs co-cultured with CD4 (+) cell treated with different groups was detected by 51Cr-release assay and was presented in the right panel with mean ± SEM (n = 5 each group, * indicated p < 0.05, ** indicated p < 0.01)

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