Fig. 4: Deficiency of Mkk4 or Mkk7 provides moderate RGC protection after CONC.

a Representative retinal flat mounts stained with cleaved caspase-3 (CASP3) in eyes 5 days after CONC or sham surgery. b Significantly fewer apoptotic cells are present in Mkk4- and Mkk7-deficient animals as compared to WT controls following CONC. N ≥ 4 per genotype per condition; *P ≤ 0.05. c Representative retinal flat mounts stained with TUJ-1 following CONC or sham surgery. d Significantly more cells remain 35 days after CONC in Mkk4- and Mkk7-deficient retinas as compared to WT controls. N ≥ 8 per genotype per genotype and condition. Scale bars: 50 μm. Error bars represent SEM