Fig. 7: CDK inhibitor reversed motor neuron death in SMA spinal organoids. | Cell Death & Disease

Fig. 7: CDK inhibitor reversed motor neuron death in SMA spinal organoids.

From: Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy

Fig. 7

a Co-staining of ISL1 (red) and SMI-32 (green) in SMA type I spinal organoids treated with DMSO and PD0332991. Cellular nuclei were counterstained with DAPI. Scale bars, 100 μm. b SMA type I and c SMA type II spinal organoids shows increased MN survival. *p < 0.05 and **p < 0.01

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