Fig. 3: Stabilized VDAC1 contributes to postconditioning-induced neuroprotection.
From: Ischemic postconditioning confers cerebroprotection by stabilizing VDACs after brain ischemia
a Immunoblots and quantification of VDACs in the hippocampal CA1 subregion 24 h after ischemia and reperfusion (I/R) in rats treated with si-VDAC1 or si-NC (n = 3 rats per group); Relative levels were normalized to ischemic postconditioning. Actin was used as a loading control. Data represent the mean ± SD of three independent experiments. *P < 0.05 versus I/R with postconditioning group; n.s., not significant; One-way ANOVA. b Left, Nissl stained hippocampal sections 5 d after I/R without or with postconditioning in rats treated with si-VDAC1 or si-NC. Scale bar, 500 μm from a to f. Scale bar, 20 μm from g to l. Right, quantification of surviving neurons in the hippocampal CA1 subfield for each group (n = 5 rats per group). Data are the mean ± SD. *P < 0.05 versus the sham group; #P < 0.05 versus the I/R with postconditioning group; one-way ANOVA
