Fig. 5: AHR activation promotes effector functions to encephalitogenic TH17 cells. | Cell Death & Disease

Fig. 5: AHR activation promotes effector functions to encephalitogenic TH17 cells.

From: TGFβ1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism

Fig. 5

a EAE clinical score of WT mice treated with AHR antagonist for 10 consecutive days (CH223191, i.p. 10 mg/kg). b Representative plots of IL-17A+, IFN-γ, and GM-CSF+ CNS-derived CD4+ T cells from vehicle and CH223191-treated EAE animals. c Frequency of cytokine-producer cells shown in b. d EAE clinical score of Rag1−/− mice recipients of WT or Ahr−/− MOG-specific TH17 cells. NS not significant; ***P < 0.001 (unpaired, two-tailed Student’s t test)

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