Fig. 5: The effect of miR-10a on KGN cells at transcriptome level.
From: MicroRNA-10a promotes granulosa cells tumor development via PTEN-AKT/Wnt regulatory axis
a Signaling pathway enrichment analysis of miR-10a-OE in GCT. b, c Pathway reporter assay showed that miR-10a could regulate PTEN, PI3K-AKT, and Wnt signaling in GCT. d MiR-10a could modulate several key factors within AKT and Wnt pathways. e PTEN expression in GCT tissues by IHC. f The predicted binding site between PTEN 3′UTR and miR-10a seed sequence. g Luciferase reporter assay showed that miR-10a could directly binding to 3′UTR of PTEN. Each bar in the figure represents the mean ± SEM of triplicates. *P < 0.05 and ** P < 0.01
