Fig. 7: The effect of miR-10a KO on KGN cells-formed tumor in vivo.
From: MicroRNA-10a promotes granulosa cells tumor development via PTEN-AKT/Wnt regulatory axis
a Timeline showing the process of establishing the GC heterotopic model. MiR-10a KO KGN or control KGN cells were injected in the back of nude mice, followed by feeding mice with dox to induce CRISPR/Cas9-mediated miR-10a KO. b The size of tumor formed from miR-10a KO KGN cells was smaller in dox-treated group (n = 5). c Histological analysis of the tumors formed from miR-10a KO cancer GC and control cancer GC. d IHC staining showed the expression of tumor suppressor PTEN, P-AKT, and FOXO1 in the miR-10a KO and control tumors
