Fig. 1: Differentiation potential, metabolic profile, and genomic integrity of early- versus late-passage F9 cells.
From: The Zen of XEN: insight into differentiation, metabolism and genomic integrity
F9 embryonal carcinoma stem-like cells differentiate towards a XEN lineage and switch their metabolic profile depending on their passage. Early-passage cells transition from OXPHOS towards glycolysis, while late-passage cells do the opposite. Additionally, late-passage cells accumulate more ROS and genetic abnormalities
