Fig. 1: Rsf1 cKO brain develops normally. | Cell Death & Disease

Fig. 1: Rsf1 cKO brain develops normally.

From: Chromatin-remodeling factor, RSF1, controls p53-mediated transcription in apoptosis upon DNA strand breaks

Fig. 1

a, b. Immunohistochemical analysis of adult brains (6-month old) with markers for neurons (Tuj1 and NeuN) and astrocytes (GFAP) (a) and oligodendrocytes (CNPase) and parvalbumin positive interneurons (b). There were no neuroanatomical differences between Rsf1ctrl and Rsf1Nes-Cre brains with regard to the hippocampus (CA1, cornu ammonis area 1; DG, dentate gyrus), caudate putamen (CPu), or cerebral cortex (CTX). c Immunohistochemical analysis of Bergmann glia (GFAP), the Purkinje cell layer (calbindin), and interneuron/Purkinje cells (parvalbumin) of the mature cerebella (Ce). No difference was found between the Rsf1ctrl and Rsf1Nes-Cre animals. Mo molecular layer; Pur Purkinje cell layer; Gr granule cell layer. d Western blot analysis of the mature (2-month old) brains with markers for neurons (NeuN), astrocytes (GFAP), oligodendrocytes (NG2, Olig1 and 2, and CNPase), and interneurons (calretinin, somatostatin, parvalbumin, GABA[GAD67], and calbindin)

Back to article page