Fig. 6: A graphic summary of the findings. | Cell Death & Disease

Fig. 6: A graphic summary of the findings.

From: Chromatin-remodeling factor, RSF1, controls p53-mediated transcription in apoptosis upon DNA strand breaks

Fig. 6

In RSF1 proficiency, p53/p300 complex stably associates with promoters (p53 RE; reponse element) of p53-target genes, which leads to the subsequent histone H3 acetylation on the promoters to induce gene expression upon DNA damage. However, RSF1 inactivation blocks the stable association of p53/p300 complex on the promoters of p53-target genes and suppresses their expressions, especially apoptotic genes. Consequently, this condition leads to escape from cell death, resulting in genomic instability

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