Fig. 1: Leptin’s effect on hippocampal synaptic plasticity. | Cell Death & Disease

Fig. 1: Leptin’s effect on hippocampal synaptic plasticity.

From: Leptin in depression: a potential therapeutic target

Fig. 1

Activation of LepRb can trigger PI3K/Akt and AMPK/Akt signaling. Both pathways can subsequently inhibit GSK3β activity. PI3K stimulation can enhance NMDA-dependent LTD and stimulate AMPA receptor exocytosis, which contributes to potentiation of excitatory synaptic transmission. Another critical event is mTOR activation, which promotes a synthesis of synaptic protein synthesis and synaptogenesis

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