Fig. 2: Leptin activates multiple signaling pathways that potentiate neuroprotection, cell survival, and proliferation. | Cell Death & Disease

Fig. 2: Leptin activates multiple signaling pathways that potentiate neuroprotection, cell survival, and proliferation.

From: Leptin in depression: a potential therapeutic target

Fig. 2

Leptin binds to LepRb and activates the PI3K/Akt signaling pathway. Activating LepRb also stimulates the MAPK-signaling pathway. Both pathways promote neuroprotection, cell survival, and proliferation. The stimulation of PI3K/Akt decreases GSK-3β activity by phosphorylating GSK-3, promoting the expression of cell proliferation genes. Activation of the LepRb leads to CREB phosphorylation and initiation of CREB-dependent transcription, which also enhances cell proliferation genes. CREB cAMP response element-binding protein

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