Fig. 8: Schematic representation of the lncRNA ODSM/miR-139-3p/ELK1 signaling pathway in osteoblasts. | Cell Death & Disease

Fig. 8: Schematic representation of the lncRNA ODSM/miR-139-3p/ELK1 signaling pathway in osteoblasts.

From: MicroRNA-139-3p regulates osteoblast differentiation and apoptosis by targeting ELK1 and interacting with long noncoding RNA ODSM

Fig. 8

In this mechanism, miR-139-3p is upregulated and interacts with downregulated lncRNA ODSM in osteoblasts under simulated microgravity conditions. As a direct and vital target, ELK1 is inhibited by miR-139-3p and then suppresses osteoblast differentiation and promotes osteoblast apoptosis

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