Fig. 5: H19/miR-29b-3p/MCL-1 regulation axis participates in the regulation of BTZ resistance in MM cells. | Cell Death & Disease

Fig. 5: H19/miR-29b-3p/MCL-1 regulation axis participates in the regulation of BTZ resistance in MM cells.

From: LncRNA H19 overexpression induces bortezomib resistance in multiple myeloma by targeting MCL-1 via miR-29b-3p

Fig. 5

a Effect of H19/miR-29b-3p co-transfection on MCL-1. b After knocking down H19, cell viability was decreased after treatment with 250 nm and 500 nm BTZ. c After co-transfection of H19/miR-29b-3p, the sensitivity to BTZ was inhibited to a certain extent after adding pcDNA-H19. d The cell inhibition rate was significantly higher with different concentrations of BTZ when the H19 was knocked down compared with the NC group. e After co-transfection of H19/mir-29b-3p, the inhibition rate in miR-29b-3p mimic group was higher than that in mimic control group, and the inhibition rate of pcDNA-H19 was decreased to some extent after adding pcDNA-H19. f and g H19/miR-29b-3p/MCL-1 regulation axis inhibited apoptosis and caused resistance. h Changes in MCL-1 and apoptosis-related proteins in MM cells by western blot

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