Fig. 7: Ser49/Ser78 sites of RXRA protein are critical for DANCR-mediated TNBC tumor growth.
From: LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA
a Effects of overexpression of GSK3β wild type or kinase deficient mutant type on RXRA phosphorylation and PI3K/Akt signaling activity in MDA-MB-231/shC and MDA-MB-231/shDANCR cells. b Effects of overexpression of RXRA wild type or mutant type on RXRA-GSK3β binding on RXRA phosphorylation and PI3K/Akt signaling activity in MDA-MB-231 with shC and shDANCR cells. c–e Effects of overexpression of RXRA wild type or mutant type on RXRA-GSK3β binding on RXRA protein binding PIK3CA ability (c), cell proliferation (d), and soft agar colony formation (e). Error bars ± SD. *P < 0.05. **P < 0.01. ***P < 0.001. Data are representative from two independent experiments
