Fig. 6: MC-dependent IL-33/ST2 signaling pathway is required for recovery from colitis. | Cell Death & Disease

Fig. 6: MC-dependent IL-33/ST2 signaling pathway is required for recovery from colitis.

From: Mast cells are essential intermediaries in regulating IL-33/ST2 signaling for an immune network favorable to mucosal healing in experimentally inflamed colons

Fig. 6

a Percentage difference in mass from day 0 for WT + IgG, WT + anti-ST2 Ab, Kit Wsh  +  IgG and Kit Wsh  +  ST2 Ab groups (6 mice/group). b Serum FITC-dextran quantified as a measure of intestinal permeability. c Measurement and comparison of colon length in remission phase. d Representative H&E plus alcian blue staining images of transverse colon (original magnification ×400). e Pathological grading of colitis. f Disease score from a comprehensive evaluation as indicated. Relative mRNA for g ZO-1, h ANGPTL2, i Reg3β, and j Reg3γ from real-time-quantification PCR. Data were pooled from three repeated experiments. Data are mean ± SD. Student t-test, *P < 0.05; **P < 0.01

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