Fig. 5: Confocal microscopy showing DR-Ab abolished the membrane loss of NKAα1 and GluR2 on the plasma membrane. | Cell Death & Disease

Fig. 5: Confocal microscopy showing DR-Ab abolished the membrane loss of NKAα1 and GluR2 on the plasma membrane.

From: DR-region of Na+/K+ ATPase is a target to treat excitotoxicity and stroke

Fig. 5

Representative immunostaining images showing colocalization of NKAα1 and GluR2 on the plasma membrane (top panel), glutamate treatment induced membrane loss of NKAα1 and GluR2 through internalization (bottom panel), and DR-Ab pretreatment, but not control normal serum, attenuated the internalization of these 2 proteins. DR: DR-Ab; Glu: glutamate (100 µM) + glycine (10 μΜ) for 30 s; NS: IgG purified from normal rat serum

Back to article page