Fig. 2: Nimbolide restores LPS-induced physiological, bronchoalveolar lavage (BAL) cytological and hematological changes. | Cell Death & Disease

Fig. 2: Nimbolide restores LPS-induced physiological, bronchoalveolar lavage (BAL) cytological and hematological changes.

From: Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-α mediated NF-κB and HDAC-3 nuclear translocation

Fig. 2

The changes in (a) body weight, (b) temperature and (c) percentage lung index were determined 12 h after LPS challenge. BALF was collected 12 h after LPS administration to measure the number of (d) total cells, (e) WBC, (f) neutrophils, (g) lymphocytes, (h) macrophages, (i) eosinophils and (j) basophils. Whole blood was collected and analyzed for (k) mean hemoglobin (Hb), (l) platelets (PLT), and (m) absolute neutrophil count after LPS induction. Data presented as mean ± SEM (n = 8 animals per group). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 are significantly different from the NC group; #P < 0.05, ##P < 0.01, ###P < 0.001, and ####P < 0.0001 are significantly different from the LPS group

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