Fig. 8: Amelioration of LPS-induced alveolar inflammation by nimbolide. | Cell Death & Disease

Fig. 8: Amelioration of LPS-induced alveolar inflammation by nimbolide.

From: Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-α mediated NF-κB and HDAC-3 nuclear translocation

Fig. 8

A schematic diagram represents the molecular mechanism of nimbolide in LPS-induced ARDS. The bacterial endotoxin, lipopolysaccharide (LPS) binds to its cognate toll-like receptor 4 (TLR-4) and the co-receptor cluster of differentiation 14 (CD14), which results in neutrophil accumulation, elevated vascular permeability, provocation of pulmonary edema. Nimbolide suppresses the nuclear translocation of NF-κB and HDAC-3. RNS- and ROS-induced ARDS is prevented by nimbolide by different canonical pathways

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