Fig. 5: FSIP1 knockout sensitizes breast cancer cells to docetaxel. | Cell Death & Disease

Fig. 5: FSIP1 knockout sensitizes breast cancer cells to docetaxel.

From: Over-expression of FSIP1 promotes breast cancer progression and confers resistance to docetaxel via MRP1 stabilization

Fig. 5

a MTT assay showing the IC50 of docetaxel in control and FSIP1 knockout MDA-MB-231 and SKBR3 cells. b Caspase-Glo 3/7 Assay to test the docetaxel sensitivity in MDA-MB-231 wild-type or FSIP1 knockout cells. c Tumor volumes in nude mice transplanted with control and FSIP1 knockout MDA-MB-231 cells and regression in tumor volumes post docetaxel administration. The *** indicates a statistical significant difference in tumor volume exists between sgNC + Docetaxel group and sgFSIP1 + Docetaxel group. d Bioluminescence imaging showing lung metastasis in the mice receiving either sgNC- or sgFSIP1-Luc-MDA-MB-231 via tail vein injection

Back to article page