Fig. 6: MRP1 can bind and be stabilized by FSIP1, and is responsible for FSIP1-mediated docetaxel resistance. | Cell Death & Disease

Fig. 6: MRP1 can bind and be stabilized by FSIP1, and is responsible for FSIP1-mediated docetaxel resistance.

From: Over-expression of FSIP1 promotes breast cancer progression and confers resistance to docetaxel via MRP1 stabilization

Fig. 6

a Co-IP and MS analysis identified the binding of FSIP1 and MRP1. b Confocal images showing the membrane-proximal co-localization of FSIP1 and MRP1. c FSIP1 knockout can decrease MRP1 levels. d MTT assay showing that overexpression of MRP1 in FSIP1 knockout cells can reverse the effect of knockout. e HPLC Analysis showing increased intracellular accumulation of docetaxel in FSIP1 knockout cancer cells, which was attenuated by MRP1

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