Fig. 4: The differential gene expressions were regulated by CUL1.

a MDA-MB-231 cells were transiently transfected with CUL1 siRNA (si-CUL1) and vector siRNA control (si-Ctrl) in triplicate. b, c The heat map and volcano plot were used to indicate the significantly differential gene expressions in MDA-MB-231 cells with CUL1 knockdown and vector control. d The classification of disease and function was conducted to enrich the differential genes in the migration of cancer cells