Fig. 6: Knockdown of SIRT2 suppresses tumour angiogenesis in vivo. | Cell Death & Disease

Fig. 6: Knockdown of SIRT2 suppresses tumour angiogenesis in vivo.

From: Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway

Fig. 6

a, b Representation of human CRC in xenografted mice. c Mean tumour volumes were measured at the indicated time points after injection of ShNC SW480 or ShSIRT2 SW480 cells (n = 8). d The weights of the tumours from sacrificed mice were examined in the ShNC SW480 cell group and the ShSIRT2 SW480 cell group. **P < 0.01. e IHC assay showing the expression of SIRT2, VEGFA and CD34 in the ShNC group and the ShSIRT2 group. Scale bar: 100 μm. f The microvascular density of the tumours was determined by quantifying the CD34 staining in the two groups. **P < 0.01. g Representative SIRT2, STAT3 and p-STAT3 staining by IHC in ShNC control and ShSIRT2 xenografted tumour tissues. h Histograms showed the expression of STAT3 and p-STAT3 in the ShNC group and the ShSIRT2 group. NS: No Significant, ***P < 0.001. Scale bar: 100 μm

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