Fig. 5: CDX2 attenuates the activity of the Wnt/β-catenin pathway in colorectal carcinogenesis. | Cell Death & Disease

Fig. 5: CDX2 attenuates the activity of the Wnt/β-catenin pathway in colorectal carcinogenesis.

From: CDX2 inhibits the proliferation and tumor formation of colon cancer cells by suppressing Wnt/β-catenin signaling via transactivation of GSK-3β and Axin2 expression

Fig. 5

a, b The luciferase reporter activities in CDX2-knockdown and CDX2-overexpressing HT-29 (a) or Caco-2 (b) cells transfected with a TOP/FOP-Flash reporter plasmid. c, d Western blot bands of cyclin D1, c-myc, and β-catenin in CDX2-knockdown and CDX2-overexpressing HT-29 (c) and Caco-2 (d) cells. All data are the mean ± SD of three independent experiments. *P < 0.05

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