Fig. 2: TNFR2 gene knockout enhanced inflammatory responses and TNFR1 gene knockout was resistant to the development of colitis. | Cell Death & Disease

Fig. 2: TNFR2 gene knockout enhanced inflammatory responses and TNFR1 gene knockout was resistant to the development of colitis.

From: Differential roles of TNFα-TNFR1 and TNFα-TNFR2 in the differentiation and function of CD4+Foxp3+ induced Treg cells in vitro and in vivo periphery in autoimmune diseases

Fig. 2

a Naive CD4+ T cells isolated from WT, TNFR1−/−, and TNFR2−/− mice were injected into Rag1−/− mice intraperitoneally. b Weights of the recipient mice were monitored after the cell transfer. c, d The colon was subjected to staining with H&E (×40, scale bars = 200 μm), and the development of colitis was evaluated blindly by two pathologists. e The morphology and size of the colon, spleen and mLNs from the recipient mice were compared. No.1 was to WT group; No.2 was to TNFR1−/− group; No.3 was to TNFR2−/− group. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001, error bars denote SD. Representative result is from six independent experiments

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