Fig. 8: rmTNFα enhances iTreg suppressive function via TNFR2 in vitro and TNFR2 mediated the suppressive capability of iTreg in vivo. | Cell Death & Disease

Fig. 8: rmTNFα enhances iTreg suppressive function via TNFR2 in vitro and TNFR2 mediated the suppressive capability of iTreg in vivo.

From: Differential roles of TNFα-TNFR1 and TNFα-TNFR2 in the differentiation and function of CD4+Foxp3+ induced Treg cells in vitro and in vivo periphery in autoimmune diseases

Fig. 8

a EAE was induced on WT mice. 9 days after the first immunization, iTreg derived from WT, TNFR1−/−, and TNFR2−/− mice were adoptively transferred into EAE model, respectively. The clinical scores were monitored. b 30 days after the first immunization, the brain and spinal cord (SC) were subjected to H&E staining (×100, scale bars = 50 μm). Foxp3, IL-17A, and IFN-γ expression in brains (c–e) and SC (f–h) were detected. *P ≤ 0.05; **P ≤ 0.01, error bars denote SD. Representative data is from six independent experiments

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