Table 1 Association of the frequency of Foxp3+ cells and S1P1 expression in tumor tissues with the clinical parameters of 116 patients with bladder carcinoma in 2003–2004

From: Sphingosine 1 phosphate receptor-1 (S1P1) promotes tumor-associated regulatory T cell expansion: leading to poor survival in bladder cancer

Clinicopathological parameter

High level of Foxp3+ (%)

P-value

High level of S1P1+ (%)

P-value

Age

 <60 y

34 (54.0)

0.445

32 (50.8)

0.568

 ≥60 y

27 (50.9)

 

27 (50.9)

 

Gender

 Female

50 (53.8)

0.390

47(50.5)

0.537

 Male

11 (47.8)

 

12 (52.2)

 

T status

 NMI

23 (39.0)

0.002*

23 (39.0)

0.008*

 MI

38 (66.7)

 

36 (63.2)

 

N status

 0

56 (53.9)

0.310

51 (49.0)

0.198

 1–3

5 (41.7)

 

8 (66.7)

 

M status

 0

57 (53.3)

0.434

55 (51.4)

0.478

 1–2

4 (44.4)

 

4 (44.4)

 

Grade

 G1

24 (51.1)

0.467

18 (38.3)

0.020*

 G2–G3

37 (53.6)

 

41 (59.4)

 

Multiplicity

 Unifocal

59 (54.6)

0.105

56 (51.9)

0.339

 Multifocal

2 (25.0)

 

3 (37.5)

 

Treatment model

 TURBT

39 (53.4)

0.482

35 (47.9)

0.266

 RC

22 (51.2)

 

24 (55.8)

 
  1. NMI nonmuscle invasive bladder cancer, MI muscle invasive bladder cancer, TURBT transurethral resection of bladder tumor, RC radical resection of bladder cancer; *means P < 0.05