Fig. 7: Macropinocytosis-like traits of silmitasertib-derived vacuoles in CRC cells. | Cell Death & Disease

Fig. 7: Macropinocytosis-like traits of silmitasertib-derived vacuoles in CRC cells.

From: CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells

Fig. 7

a DLD-1 cells were transfected with a plasmid encoding Rab7-GFP for 24 h and then treated with 25 μM silmitasertib for 6 h and finally visualized by confocal microscopy. b Cells were treated with silmitasertib as in a, then incubated for 1 h with 50 μg/ml FITC-dextran (green) and living cells were visualized by confocal microscopy. Black arrowheads indicate the vacuoles highlighted in white squares. Representative images are shown (n = 3); Bars: 10 μm

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