Fig. 8: Pivotal role of CK2 in life and death of CRC cells by regulation of methuosis. | Cell Death & Disease

Fig. 8: Pivotal role of CK2 in life and death of CRC cells by regulation of methuosis.

From: CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells

Fig. 8

In untreated cells (left) an aberrantly elevated expression/activity of CK2 promotes upregulation of mTORC1 and hence downregulation of ULK-1, promoting autophagy-independent cell viability. Here, MKK4 may also be downregulated by CK2, thereby not affecting macropinocytosis. In silmitasertib-treated cells (right), however, a putative MKK4-dependent macropinocytosis is promoted, where early massive formation of acidic vacuoles (LC3-II−/LAMP1+/Rab7+) then triggers a G2/M arrest and ultimately methuosis-like cell death. Consequently, CRC cells are unable to form tumors

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