Fig. 1: Profiling lysine acetylation proteome in rat islets. | Cell Death & Disease

Fig. 1: Profiling lysine acetylation proteome in rat islets.

From: The pivotal role of protein acetylation in linking glucose and fatty acid metabolism to β-cell function

Fig. 1

a Rat islets were stimulated with 3.3 or 16.7 mM glucose in the presence or absence of 200 nM TSA and 5 mM NAM for 1 h, and then insulin secretion was measured. b Rat islets were treated with 200 nM TSA and 5 mM NAM at 3.3 mM glucose for the indicated time and then insulin secretion was measured. c Proteomic workflow for the identification of acetylated sites and proteins in rat islets. d Comparison of the acetylated proteins identified in the present study (red circle) with that in CPLM database (blue circle). e Comparison of the acetylated lysine sites identified in the present study (red circle) with that in CPLM database (blue circle). f Distribution of the number of acetylated sites per protein. *p < 0.05, **p < 0.01 vs. control (CON)

Back to article page