Fig. 3: Distal TEC-specific Atg7 deletion activates TGF-β/Smad4 signaling after UUO. | Cell Death & Disease

Fig. 3: Distal TEC-specific Atg7 deletion activates TGF-β/Smad4 signaling after UUO.

From: Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway

Fig. 3

a Representative immunoblots and b densitometry of expression of TGF-β and Smad4. c Immunostaining of expression of TGF-β, showing increased TGF-β in the obstructed distal TEC-specific Atg7 KO mice. Scale bars, 50 μm. (n = 5, densitometry; *P < 0.01 versus kidney of WT mice with sham operation; †P < 0.01 versus kidney of tubular epithelial cell-specific Atg7 KO mice with sham operation; ‡P < 0.01 versus obstructed kidney of WT mice 7 days after UUO)

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