Fig. 4: Distal TEC-specific Atg7 deletion enhances tubular EMT-like phenotype and the accumulation of interstitial myofibroblasts change after UUO. | Cell Death & Disease

Fig. 4: Distal TEC-specific Atg7 deletion enhances tubular EMT-like phenotype and the accumulation of interstitial myofibroblasts change after UUO.

From: Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway

Fig. 4

a Representative immunoblots and b densitometry of expression of E-cadherin, α-SMA and vimentin. c Immunostaining and quantification of E-cadherin. Scale bars, 100 μm. d Immunostaining and quantification of α-SMA. Scale bars, 100 μm. e Immunostaining and quantification of and vimentin. Scale bars, 100 μm. f Immunostaining and quantification of FSP-1 Scale bars, 100 μm. (n = 5, densitometry; *P < 0.01 versus kidney of WT mice with sham operation; †P < 0.01 versus kidney of tubular epithelial cell-specific Atg7 KO mice with sham operation; ‡P < 0.01 versus obstructed kidney of WT mice 7 days after UUO)

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